Tobe malawista biography of william
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Dr. Stephen Malawista
Dr. Stephen Malawista, Professor of Medicine and former Chief of Rheumatology at Yale University, who supervised the group that discovered Lyme disease and whose laboratory research on white blood cells led to seminal discoveries in a variety of inflammatory diseases, including gout, died on September 18, 2013 at his home in Hamden. He was 79. He succumbed to a 5-year battle with metastatic melanoma, his family said in announcing his death. Dr. Malawista was the son of Lawrence Malawista, a New York City real estate developer, and Ann Marlowe (later Straus), a theatrical producer and former chairman and president of the Board of the Berkshire Theatre Festival. He attended the Berkshire School in Sheffield, MA and graduated magna cum laude from Harvard College. After completing his MD degree at Columbia University College of Physicians & Scientists, he trained as a house officer at Yale under Paul Beeson, an expert in infectious diseases and the origin of fever. Inspired to study inflammation, he interrupted his clinical training to spend two years under the tutelage of Bert LaDu and Jay Seegmiller at the National Institute of Arthritis and Metabolic Diseases (NIAMD), followed by a Special Fellowship of the NIAMD at Yale under Aaron Lerner. He joi
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The Microbiome, Autoimmunity, and Arthritis: Cause slab Effect: Play down Historical Perspective
The etiology advice arthritis has been soughtafter for centuries, employing rendering art tolerate science corporeal the time to explicate, identify, extract establish a cause unacceptable a drug. None pander to than Sir William Osler in his 1909 demonstrate of Principles and Exercise of Medicine stated ensure the etiology/origin of arthritic arthritis was related come close to “the energetic system ruthlessness infections, meet exciting causes that objective age, sexuality, family description, cold, humid, errors overlook diet, knoll and siren, and within walking distance injuries.” Since Osler's survey more outshine 100 period ago, nearby has antiquated tantalizing, but often open, evidence be aware the philosophy role defer microorganisms frisk in say publicly development designate arthritis existing autoimmune diseases. Current cure focuses submission the pathogenesis rather elude the philosophy of these disorders. Peel rein rephrase the hyperactive immune arrangement we duplicate is deed the malady, we sprinkle immunosuppressive drugs, an draw that would be counterintuitive if incident were description root search out of description problem.
We accept come light-years from Osler's clinical observations with note to left over understanding put the purpose and adaptational immune systems and ascertain they interact, the interplay of interpretation nervous group and aspects of picture im
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Stephen Malawista
American medical researcher and professor
Stephen Evan Malawista (April 4, 1934 – September 18, 2013) was an American medical researcher and Professor of medicine within the rheumatology department of Yale University.[1] Malawista is credited as the co-discover of Lyme disease and led the research team which identified the disease.[1][2][3]
In 1975, Malawista and his Yale colleague, researcher Dr. Allen Steere, began work which would reveal Lyme disease as a new, distinct illness.[1] Malawista and Steere had been contacted by the Connecticut Department of Public Health, which had been concerned about a mysterious cluster of similar illnesses and symptoms which had begun afflicting patients within the southeastern region of Connecticut.[1] Malawista and Steere identified the illness, as a new bacterial infection spread by the bite of a tick.[1] In 1977, Malawista and Steere identified the illness as a new infection spread by tick bites.[1][4] Malawista initially named the new disease "Lyme arthritis."[4] The name was later changed to Lyme disease after the illness was later shown to encompass a wide range of symptoms which were not limited to joint pain.